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New research · Ophthalmology
Diabetes care · 12h
Meta-analysisDiabetes care · 2026

GLP-1 Receptor Agonists and Risk of Optic Nerve or Vision-Threatening Events in Patients With Type 2 Diabetes or Cardiometabolic Diseases: A Meta-analysis of Randomized Controlled Trials.

Hoi-Ying Li, Tsz-Kwan Chan, Kendrick Co Shih … Yap-Hang Chan
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OphthalmologyMeta-analysis

GLP-1 receptor agonists not linked to higher risk of vision-threatening events in trials

GLP-1 Receptor Agonists and Risk of Optic Nerve or Vision-Threatening Events in Patients With Type 2 Diabetes or Cardiometabolic Diseases: A Meta-analysis of Randomized Controlled Trials.

Hoi-Ying Li … Yap-Hang Chan
Diabetes care · 2026
Background

Data concerning glucagon-like peptide 1 receptor agonists (GLP-1 RAs) on risk of ischemic optic neuropathy (ischemic optic neuropathy) are conflicting.

Purpose

We synthesize current evidence of GLP-1 RAs on risk of optic nerve or vision-threatening events from randomized controlled trials (randomized controlled trials) in patients with type 2 diabetes or cardiometabolic diseases.

Results

checked for eye and optic nerve problems - no clear increase or decrease found

OR by subgroup · 95% CI
null = 1
primary end point
1.20
ION
1.50
vision loss/disturbance events
1.08
More results

DATA EXTRACTION: Primary outcome was a composite of optic nerve and/or vision-threatening serious adverse events, including ischemic optic neuropathy, ocular ischemic syndrome, papilledema, blindness, blurred vision, visual impairment, and reduced visual acuity.

Odds ratios (ORs) were derived.

DATA SYNTHESIS: Type 2 diabetes occurred in 76.4% of participants.

More results

LIMITATIONS: randomized controlled trials reported vision-threatening events as adverse events rather than as prespecified outcomes.

“
Conclusion

Based on a large number of patients who contributed to a meta-analysis of randomized controlled trials involving participants with type 2 diabetes and cardiometabolic disease, GLP-1 RAs were not associated with an increased risk of optic nerve/vision-threatening events.

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