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New research · Ophthalmology
Pituitary · 13h
Cohort studyPituitary · 2026

Pituitary metastasis as an endocrine-neuro-ophthalmologic emergency: clinical red flags and outcomes from a contemporary tertiary-center series.

José Calixto Llumiquinga Marcayata, Jacqueline Miyuki Viel, Matheo Augusto Morandi Stumpf … Rafael Loch Batista
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OphthalmologyCohort study

Pituitary metastasis carries a very short survival after diagnosis.

Pituitary metastasis as an endocrine-neuro-ophthalmologic emergency: clinical red flags and outcomes from a contemporary tertiary-center series.

José Calixto Llumiquinga Marcayata … Rafael Loch Batista
Pituitary · 2026
Purpose

To characterize the clinical presentation, endocrine phenotype, and outcomes of pituitary metastasis in a contemporary tertiary-center cohort, with emphasis on clinically actionable diagnostic red flags.

Methods

We conducted a retrospective single-center case series of 14 consecutive patients diagnosed with pituitary metastasis between 2010 and 2025.

n = 11 patients
6.5
Results
6.5
months
half died within about six months of diagnosis
n = 11 patients
More results

Median age was 52.5 years, and 71.4% of patients were women.

Hypopituitarism (64.3%), arginine vasopressin deficiency (50.0%), and visual impairment (50.0%) were frequent at presentation.

Breast cancer was the most common primary tumor (28.6%).

More results

Serum prolactin levels, available in 11 patients, were uniformly below the range typically expected for macroprolactinoma despite large sellar masses.

“
Conclusion · 1 of 2

Pituitary metastasis frequently presents with combined endocrine dysfunction and neuro-ophthalmologic compromise, occasionally as an acute sellar emergency.

Conclusion · 2 of 2

In oncologic patients with sellar lesions, the combination of AVP-D, visual deterioration, and non-prolactinoma-range hyperprolactinemia should raise suspicion for pituitary metastasis and prompt urgent endocrine and local evaluation.

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