New research · OphthalmologyBMC neurology · 13hCohort studyBMC neurology · 2026The association between diplopia and clinical phenotypes in spinocerebellar ataxia type 3.Mei Zheng, Mao-Lin Cui, Wei Lin … Shi-Rui Gan +2 moreRead paper Copy citationOphthalmologyCohort studyModerate evidenceVisual impairment is linked to higher odds of diplopia in spinocerebellar ataxia type 3.The association between diplopia and clinical phenotypes in spinocerebellar ataxia type 3.Mei Zheng … Shi-Rui GanBMC neurology · 2026BackgroundSpinocerebellar ataxia type 3 (SCA3) is a rare monogenic hereditary neurodegenerative disease.PurposeOur objective is to investigate the association between diplopia and the clinical phenotype of SCA3.MethodsWe conducted a retrospective analysis of 182 patients with SCA3.n = 182 patientsResultspoor vision roughly doubles the odds of seeing double45.6%Diplopia54.4%No diplopiaMore resultsIn this study, the frequency of diplopia among subjects was 45.6%, while 54.4% of subjects did not experience diplopia.The diplopia group exhibited significantly higher ICARS scores (p = 0.002) .“Conclusion · 1 of 2Diplopia is common in patients with SCA3. Visual impairment has been identified as a risk factor for developing diplopia.Conclusion · 2 of 2Additionally, diplopia is associated with the severity of ataxia, necessitating intensive focus and interventions in the care of SCA3 patients.Read full abstractRead paper LikeCommentRepostSendPractice