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New research · Ophthalmology
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 13h
Cohort studyJournal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2026

Baseline Features of Optic Neuritis in South Korea: A Retrospective Multicenter Study.

Yeonji Jang, Yungju Yoo, Haeng-Jin Lee … Ungsoo S Kim
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OphthalmologyCohort study

Most optic neuritis cases in Korean patients were seronegative, not antibody-associated

Baseline Features of Optic Neuritis in South Korea: A Retrospective Multicenter Study.

Yeonji Jang … Ungsoo S Kim
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2026
Background

To investigate the clinical features and serologic test results of optic neuritis through a multi-institutional study in Korea.

Methods

The is a retrospective cohort study from multicenters (21 centers) in Korea.

n = 181 Korean patients
Results

over half tested negative for both antibodies checked, no clear immune cause found

8.2%
Anti-AQP4 antibody pos
32.2%
Anti-MOG antibody posi
56.7%
Negative
More results

Of the cohort, 55.2% were female, and 18.2% had bilateral involvement.

At the onset, 67.4% of patients presented with ocular pain, and 98.3% of patients had visual impairment.

In addition, 27.1% of patients experienced neurologic symptoms such as headaches and dizziness.

More results

The average visual acuity was 1.08 logMAR, with 65.7% of patients showing optic disc swelling.

“
Conclusion · 1 of 2

In Korea, idiopathic optic neuritis was the most common, followed by myelin oligodendrocyte glycoprotein-related optic neuritis. Accordingly, clinical manifestations showed different tendencies depending on the causative disease.

Conclusion · 2 of 2

Therefore, understanding racial characteristics and appropriate planning during the diagnosis and treatment of optic neuritis are necessary.

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