Self-assembled non-steroidal anti-inflammatory drug-peptide hydrogel to effectively mitigate ocular inflammation.

The generated hydrogel was thoroughly characterized using a rheometer and transmission electron microscopy (transmission electron microscopy).

The proposed Pra-ffd hardly caused cytotoxicity in RAW 264.7, L929, and human corneal epithelial cells (human corneal epithelial cells).

Using an endotoxin-induced uveitis (endotoxin-induced uveitis) rabbit model, we demonstrated that topical instillation of Pra-ffd hydrogel effectively mitigated the inflammatory response in the anterior chamber and significantly reduced the entry of inflammatory cells from the circulation by preserving the integrity of the blood-aqueous humor barrier.