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Cohort studyJournal of ophthalmic inflammation and infection · 2026

Culture-proven endogenous endophthalmitis: ocular and systemic clinical features and outcomes.

Charles Zhang, Mariam Tadross, Sujin Kang … Harry W Flynn

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OphthalmologyCohort study

Fungal organisms caused nearly half of culture-proven endogenous endophthalmitis cases.

Culture-proven endogenous endophthalmitis: ocular and systemic clinical features and outcomes.

Charles Zhang … Harry W Flynn

Journal of ophthalmic inflammation and infection · 2026

Purpose

To report the clinical presentation, systemic associations, microbiologic spectrum, management strategies, and treatment outcomes of patients with culture-proven endogenous endophthalmitis.

Methods

A retrospective review of medical records was conducted of patients with culture-proven endogenous endophthalmitis between 2013 and 2024.

n = 50 eyes

46%

Results

46%

fungal infections, not bacteria, were the culprit in nearly half of cases

n = 50 eyes

More results

Of these, 30/41 (73%) presented in an outpatient setting.

The most common presenting symptom was blurred vision in 36/41 (88%) with only 16/41 (39%) presenting with systemic symptoms.

Blood cultures were positive in 23/41 (56%).

More results

A systemic source of infection was identified in 23/41 (56%), most often associated with indwelling medical devices in 7/23 (30%).

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Conclusion · 1 of 2

Endogenous endophthalmitis was associated with a fungal source in 46% of cases and was not associated with systemic symptoms in 61% of cases. In the current study, indwelling medical devices remain an important source of infection.

Conclusion · 2 of 2

Despite prompt treatment, visual outcomes were generally poor.

Post

Culture-proven endogenous endophthalmitis: ocular and systemic clinical features and outcomes.

Fungal organisms caused nearly half of culture-proven endogenous endophthalmitis cases.

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