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New research · Ophthalmology
Ocular immunology and inflammation · 14h
Cohort studyOcular immunology and inflammation · 2026

Real-Life Evaluation of the Revised IWOS, Modified Abad and SUN Criteria in a Multicenter Cohort of 409 Patients with Sarcoid Uveitis.

Margot Cargnelutti, Robin Jacquot, Thomas El-Jammal … Pascal Sève
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OphthalmologyCohort study

Modified Abad criteria were most sensitive for diagnosing sarcoid uveitis among three systems

Real-Life Evaluation of the Revised IWOS, Modified Abad and SUN Criteria in a Multicenter Cohort of 409 Patients with Sarcoid Uveitis.

Margot Cargnelutti … Pascal Sève
Ocular immunology and inflammation · 2026
Purpose

To evaluate and compare the International Workshop on Ocular Sarcoidosis (IWOS) revised diagnostic criteria, the modified Abad diagnostic criteria, and the Standardization of Uveitis Nomenclature (Standardization of Uveitis Nomenclature) classification criteria in patients with sarcoid uveitis in a real-life setting.

Methods

This multicenter cohort study included 409 patients with sarcoid uveitis managed at the Hospices Civils de Lyon between 2003 and 2024.

n = 409 patients
Results

checked correctly identified nearly all true sarcoid uveitis cases - higher is better

Modified Abad
99.3%
IWOS
90.1%
SUN
83.4%
More results

Uveitis was often bilateral (79.1%) and granulomatous (73.7%).

Panuveitis accounted for 43.3% of cases and anterior uveitis for 23.7% of cases.

Sarcoid uveitis was histologically confirmed in 71.5% of patients.

More results

Exclusion from IWOS criteria was due to insufficient ophthalmologic signs (65.0%) or bilateral hilar lymphadenopathy absence (70.0%).

“
Conclusion · 1 of 2

The modified Abad criteria were the most sensitive for diagnosing sarcoid uveitis. The IWOS criteria sensitivity was lower due to stricter ophthalmologic and radiologic requirements.

Conclusion · 2 of 2

The Standardization of Uveitis Nomenclature criteria sensitivity was lower due to stricter radiologic criteria and exclusion of patients with a positive tuberculosis screening.

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