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New research · Ophthalmology
Ocular immunology and inflammation · 14h
Cohort studyOcular immunology and inflammation · 2026

Neuro-Behçet's Syndrome Developing During Follow-Up for Behçet Uveitis: A Tertiary Uveitis Center Experience.

Nilufer Zorlutuna Kaymak, Ezgi Tanyeri Kılınç, Ilknur Sunğu … Mehmet Engin Tezcan
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OphthalmologyCohort study

Neuro-Behçet's syndrome developed in 4% of Behçet uveitis patients during follow-up.

Neuro-Behçet's Syndrome Developing During Follow-Up for Behçet Uveitis: A Tertiary Uveitis Center Experience.

Nilufer Zorlutuna Kaymak … Mehmet Engin Tezcan
Ocular immunology and inflammation · 2026
Purpose

To evaluate the clinical, neurological, and neuropsychiatric characteristics, subtype distribution, and multidisciplinary management in patients developing Neuro-Behçet's syndrome (NBS) during follow-up for Behçet uveitis (BU).

Methods

This retrospective study included 12 patients with panuveitis who developed NBS during follow-up for uveitis.

n = 12 patients
4%
Results
4%
checked patients over time: about 1 in 25 later developed brain/nerve inflammation
n = 12 patients
More results

Parenchymal involvement was the most frequent subtype (50%), primarily affecting the brainstem, while neuropsychiatric symptoms occurred in 41.7% of patients.

Neuropsychiatric cases demonstrated higher pathergy positivity and skin lesions, whereas genital ulcers were more common in parenchymal and mixed involvement.

More results

Notably, 41.7% of patients had active uveitis at the time of NBS onset, suggesting that neurological involvement can occur independently of ocular inflammatory activity.

At final follow-up, visual acuity remained stable ( p > 0.05) with no permanent neurological sequelae.

“
Conclusion · 1 of 3

In this uveitis cohort, NBS developed in 4% of patients with BU.

Conclusion · 2 of 3

Because neurological involvement may occur subclinically or independently of ocular activity, clinicians should maintain a high index of suspicion for neurological and neuropsychiatric manifestations.

Conclusion · 3 of 3

A prompt multidisciplinary approach and timely treatment escalation are essential to prevent permanent neurological damage in this patient population.

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