Acute tear-film disruption in treatment-naive acute anterior uveitis: A retrospective case-control study.
Tear breakup time is markedly shorter in eyes with acute anterior uveitis than in healthy eyes.
Acute tear-film disruption in treatment-naive acute anterior uveitis: A retrospective case-control study.
The study aimed to quantify the acute tear-film disruption in treatment-naive, 1st-onset noninfectious acute anterior uveitis (acute anterior uveitis) and identify independent and modifiable determinants.
Retrospective case-control study enrolling 180 acute anterior uveitis eyes and 90 age-/sex-matched healthy controls.
on average, eyes had less tear-film stability, meaning drier, less protected eye surfaces
Multivariable linear regression with bootstrap correction determined predictors of shorter NIBUT.
Tear meniscus height (-81 μm), Schirmer-I (-5.3 mm) and Ocular Surface Disease Index (+24 points) all worsened (P < .001).
Independent reductions in NIBUT: anterior-chamber cells ≥ 2+ (-1.79 seconds), flare ≥ 3+ (-1.23 seconds), concomitant meibomian gland dysfunction (-0.96 seconds) and daily screen time > 8 hours (-0.59 seconds); adjusted R2 = 0.38, optimism-corrected R2 = 0.35.
While these findings suggest a potential role for early ocular-surface protection, effect sizes represent upper-bound estimates requiring confirmation in unscreened populations before routine clinical application.