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New research · Ophthalmology
Ocular immunology and inflammation · 13h
Cohort studyOcular immunology and inflammation · 2026

Sarcoid Uveitis Epidemiology, Systemic Treatment, and Complications: A Large United States National Database Study.

Fatma F Shakarchi, Jawad Muayad, Ahmed F Shakarchi … Ahmed B Sallam
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OphthalmologyCohort study

Over a third of sarcoid uveitis patients develop cataract within 5 years of diagnosis.

Sarcoid Uveitis Epidemiology, Systemic Treatment, and Complications: A Large United States National Database Study.

Fatma F Shakarchi … Ahmed B Sallam
Ocular immunology and inflammation · 2026
Purpose

To determine the epidemiology of sarcoidosis and sarcoid uveitis and the investigations, systemic treatments, and complications of sarcoid uveitis on a population level.

Methods

We performed a retrospective cohort study using the TriNetX United States Collaborative Network to identify cases using the International Classification of Diseases, 10th Revision (ICD-10) codes.

n = 108,597,869 patients
Results

more than a third had cloudy-lens (cataract) damage after diagnosis

Cataract
35.7%
Glaucoma
30.6%
Cystoid macular edema
16.1%
Low vision and blindne
10.2%
More results

Among 108,597,869 patients, 146,356 had sarcoidosis, and 5,609 had sarcoid uveitis, with mean ages of 62.6 years and 58.8 years, respectively, and female predominance in both cohorts (56.5-60.4%).

Most sarcoidosis patients were White (53.4%), while the majority of sarcoid uveitis patients were Black or African American (43.68%).

More results

Almost 4% of patients with sarcoidosis developed uveitis within 5 years, and the incidence of uveitis in sarcoidosis patients remained relatively constant, while the prevalence of both sarcoidosis in our cohort and uveitis in sarcoidosis patients increased in our study period.

“
Conclusion

Sarcoidosis prevalence rose over 12 years, but uveitis rates remained stable. One-third of sarcoid uveitis patients developed major ocular complications, highlighting the disease burden.

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