Retinal Pigment Epithelium Undulations in Primary Vitreoretinal Lymphoma: An Under-Recognised OCT Biomarker.
Retinal pigment epithelium undulations on OCT linked to 4-fold higher odds of partial regression
Retinal Pigment Epithelium Undulations in Primary Vitreoretinal Lymphoma: An Under-Recognised OCT Biomarker.
To determine the significance of retinal pigment epithelium (retinal pigment epithelium) undulations in primary vitreoretinal lymphoma (primary vitreoretinal lymphoma) and evaluate the association of retinal pigment epithelium undulations, intraretinal infiltration, and sub-retinal pigment epithelium/subretinal lesions with severity indicators, including partial regression, subsequent central nervous system (central nervous system) involvement, and recurrence.
It is a multicentred, retrospective observational study which included 134 biopsy-proven primary vitreoretinal lymphoma eyes from Asian and American populations.
Retinal pigment epithelium undulations meant about 4 times higher odds of only partial disease regression
The median age of the patients was 67 years (range 59-71), and the sex distribution was 72 females (54%) and 62 males (46%).
On OCT, 35 (26%) eyes showed retinal pigment epithelium undulations, which were more common in Asians (61%) than in the American population (16%).
In addition, 67 (50%) eyes exhibited sub-retinal pigment epithelium/subretinal hyperreflective lesions, and 45 (34%) eyes had intraretinal lesions.
Retinal pigment epithelium undulation is more common in Asians than in the American population.
It is a marker of disease severity associated with partial regression of the disease, whereas intraretinal lesions are associated with an increased risk of subsequent central nervous system involvement.