What are the key predictors of visual function recovery in uveitis? A systematic review and meta-analysis…

Meta-analysisInflammation research : official journal of the European Histamine Research Society ... [et al.]· Apr 2026

What are the key predictors of visual function recovery in uveitis? A systematic review and meta-analysis unraveling structural, genetic, and immunological determinants.

Kai-Yang Chen, Hoi-Chun Chan, Chi-Ming Chan

UveitisMeta-analysisPrognosisQ1IF 6.2

Preserved retinal structure linked to much higher odds of good visual acuity recovery in uveitis.

What are the key predictors of visual function recovery in uveitis? A systematic review and meta-analysis unraveling structural, genetic, and immunological determinants.

Kai-Yang Chen … Chi-Ming Chan

Inflammation research · Apr 2026

Background

Uveitis represents a heterogeneous inflammatory disorder of the uveal tract that remains a major cause of preventable blindness worldwide.

Purpose

To identify and synthesize key predictors of visual function recovery in patients with uveitis-associated vision loss through a systematic review and meta-analysis.

Methods

Eligible randomized controlled trials and cohort studies evaluating clinical, structural, or genetic predictors of visual recovery were included.

Results

Better retinal structural preservation was linked to over 2.5-fold higher odds of achieving 20/200 vision or better.

OR 2.65 (95% CI 2.65 to 2.65)

null 1

2.65

CI excludes the null - significant

More results

Fourteen studies met inclusion criteria.

Meta-analysis demonstrated a significant overall improvement in best-corrected visual acuity (BCVA; SMD = 0.303; p < 0.001).

More results

Genetic polymorphisms in CCR2/CCR5 were associated with visual outcomes, although genetic evidence was limited and requires independent validation; preserved retinal architecture and longer treatment duration were consistently associated with better visual recovery.

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Conclusion · 1 of 2

Visual function recovery in uveitis depends on structural preservation, inflammation control, and genetic determinants.

Conclusion · 2 of 2

Early detection and sustained treatment targeting retinal integrity are essential to prevent irreversible vision loss and enhance patient-specific prognostication.

What are the key predictors of visual function recovery in uveitis? A systematic review and meta-analysis unraveling structural, genetic, and immunological determinants.

What are the key predictors of visual function recovery in uveitis? A systematic review and meta-analysis unraveling structural, genetic, and immunological determinants.

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