Nearly one-third of patients develop dry eye syndrome after orbital tumor radiotherapy.
Risk of dry eye syndrome after radiotherapy for orbital tumors: a systematic review and meta-analysis.
Mengyu Zong, Changyong Li
Frontiers in oncology · 2026
Background
This systematic review aimed to investigate the risk of developing dry eye syndrome following radiotherapy for orbital tumors.
Purpose
This study aimed to provide insights for formulating radiotherapy suggestions for orbital tumors and preventing dry eye syndrome.
Methods
This systematic review collected literature published in PubMed, EBSCO, and Web of Science prior to December 1,2025 concerning dry eye syndrome induced by radiotherapy for orbital tumors.
n = 1,602 patients
31%
Results
31%
checking for dryness/irritation, having radiotherapy raised the risk of dry eyes
n = 1,602 patients
More results
No significant publication bias was detected.
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Conclusion · 1 of 2
Radiotherapy for orbital tumors significantly increases the risk of Dry Eye Syndrome.
Conclusion · 2 of 2
Although statistical interactions were not significant, trends suggest that older age, higher radiation dose, and shorter follow-up may elevate Dry Eye Syndrome risk, underscoring the need for tailored monitoring and preventive care.