Risk of dry eye syndrome after radiotherapy for orbital tumors: a systematic review and meta-analysis.

Systematic reviewFrontiers in oncology· 2026

Risk of dry eye syndrome after radiotherapy for orbital tumors: a systematic review and meta-analysis.

Mengyu Zong, Changyong Li

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CorneaSystematic reviewClinical practiceQ2IF 3.1

Nearly one-third of patients develop dry eye syndrome after orbital tumor radiotherapy.

Risk of dry eye syndrome after radiotherapy for orbital tumors: a systematic review and meta-analysis.

Mengyu Zong, Changyong Li

Frontiers in oncology · 2026

Background

This systematic review aimed to investigate the risk of developing dry eye syndrome following radiotherapy for orbital tumors.

Purpose

This study aimed to provide insights for formulating radiotherapy suggestions for orbital tumors and preventing dry eye syndrome.

Methods

This systematic review collected literature published in PubMed, EBSCO, and Web of Science prior to December 1,2025 concerning dry eye syndrome induced by radiotherapy for orbital tumors.

n = 1,602 patients

31%

Results

31%

checking for dryness/irritation, having radiotherapy raised the risk of dry eyes

n = 1,602 patients

More results

No significant publication bias was detected.

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Conclusion · 1 of 2

Radiotherapy for orbital tumors significantly increases the risk of Dry Eye Syndrome.

Conclusion · 2 of 2

Although statistical interactions were not significant, trends suggest that older age, higher radiation dose, and shorter follow-up may elevate Dry Eye Syndrome risk, underscoring the need for tailored monitoring and preventive care.

Risk of dry eye syndrome after radiotherapy for orbital tumors: a systematic review and meta-analysis.

Risk of dry eye syndrome after radiotherapy for orbital tumors: a systematic review and meta-analysis.

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