Optical Coherence Tomography-Derived Excavation Index and Structure-Function Damage in Glaucoma.
Excavation Index rises progressively with glaucoma severity from control to advanced disease.
Optical Coherence Tomography-Derived Excavation Index and Structure-Function Damage in Glaucoma.
This study proposes the Excavation Index (Excavation Index), a novel optical coherence tomography-based parameter designed to quantify the optic disc excavation.
A total of 107 eyes (23 controls, 84 with primary open-angle glaucoma of varying severity) underwent OCT and visual field testing.
excavation index rises with worsening glaucoma severity
In multivariate analysis, intraocular pressure, retinal nerve fiber layer thickness and LC curvature index were independently associated with Excavation Index (P<0.05).
ROC analysis showed that AUC of Excavation Index was 0.860, comparable to LC curvature index (AUC=0.864,P=0.923).
Excavation Index significantly differentiated control from all disease stages (all P<0.01).
The Excavation Index provides a reliable measurement of glaucomatous optic disc excavation.
Its structural-functional correlations suggest potential utility as a complementary biomarker for disease staging and monitoring of optic disc excavation in glaucoma.
Excavation Index may represent a promising parameter for the detection of early-stage glaucoma, suggesting sensitivity to glaucomatous changes; however, further studies are needed to confirm its diagnostic role.