US Incidence and Demographics of Ocular Surface Squamous Neoplasia in the IRIS® Registry 2014-2021.
Ocular surface squamous neoplasia incidence in the US nearly tripled in the IRIS Registry from 2014 to 2021.
US Incidence and Demographics of Ocular Surface Squamous Neoplasia in the IRIS® Registry 2014-2021.
To determine the incidence and demographics of ocular surface squamous neoplasia (ocular surface squamous neoplasia) in the United States using the IRIS® Registry (Intelligence Research in Sight).
A total of 13 924 unique eyes from 13 383 patients.
Registry-recorded ocular surface squamous neoplasia cases per year nearly tripled over the study period.
The annual incidence from 2014 to 2021 in the IRIS Registry was 3.4 per 100 00 patient-years.
The average age was 67 years, with 88% of patients older than 50 years and 62% older than 65 years.
Demographics of the affected cohort were 63.8% male, 65% White, and 10% Hispanic.
Forty percent of patients with ocular surface squamous neoplasia had a history of smoking, and 39% of patients were in southern US states based on US Census classification.
This study used the IRIS Registry as a database for the incidence and demographics of ocular surface squamous neoplasia.
Our demographic results are consistent with other studies showing a higher incidence in older, White, and male patients.
This study demonstrated that as of 2021 there are at least 2100 new ocular surface squamous neoplasia cases per year in the United States and that incidence increased from 2014 to 2021.
The use of the topical immuno-chemotherapy interferon remained a popular treatment modality for ocular surface squamous neoplasia from 2014 to 2021.