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New research · Ophthalmology
Indian journal of ophthalmology · 14h
Cohort studyIndian journal of ophthalmology · 2025

Survival outcomes and prognosis predictors of uveal melanoma from Indian population.

Payal N Shah, Mahesh Shanmugam, Neha M Kagathi … Sunita Mohan
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OphthalmologyCohort study

Most metastases in choroidal melanoma occur within the first five years

Survival outcomes and prognosis predictors of uveal melanoma from Indian population.

Payal N Shah … Sunita Mohan
Indian journal of ophthalmology · 2025
Background

Choroidal melanoma is an uncommon malignancy in the Asian Indian population, with limited survival data available for this demographic.

Purpose

This study aims to evaluate the survival outcomes and prognostic factors in a cohort of Asian Indian patients with choroidal and ciliochoroidal melanoma.

Methods

We conducted a retrospective analysis of 150 patients with choroidal and ciliochoroidal melanoma between 2011 and 2023 at a single tertiary eyecare and ocular oncology center in India.

n = 150 patients
Results

in this study, most cancer spread happened within five years, not later

HR by subgroup · 95% CI
null = 1
78
4.24
24
6.38
More results

The melanoma metastasis-related mortality was 16%.

The five-year survival was more than 90% in stages T1 and T2, 80% in stage T3, while it dropped to almost 65% in stage T4.

More results

The five year disease specific survival (disease specific survival) was 84% (95% CI: 77%-90%), and the 10 year disease specific survival was 66% (95% CI: 53%-77%).

“
Conclusion · 1 of 2

This study highlights favorable survival outcomes in Indian patients with choroidal melanoma, despite a younger age at presentation.

Conclusion · 2 of 2

The critical window for metastasis management is within the first five years, underscoring the necessity of structured follow-up protocols.

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