Post

New research · Ophthalmology
Clinical & experimental ophthalmology · 15h
Animal / preclinicalClinical & experimental ophthalmology · 2025

Investigating Microinvasive Intra-Ocular Biopsy.

Jared Ching, Shohei Kitahata, Hinako Ichikawa, Kazuaki Kadonosono
Read paper
OphthalmologyAnimal / preclinical

Microneedle anterior chamber puncture caused zero aqueous leakage

Investigating Microinvasive Intra-Ocular Biopsy.

Jared Ching … Kazuaki Kadonosono
Clinical & experimental ophthalmology · 2025
Background

Current minimally invasive methods of intraocular biopsy are confined to small gauge (G) needles and subretinal cannulae that can be prone to wound leakage at the biopsy site.

Methods

Human uveal melanoma (UM 92-1) and retinoblastoma (Y79) cancer cell lines were aspirated using microneedles of different sizes with a vitrectomy set up, and cell viability was analysed.

Results

no fluid leaked from the eye after the tiny-needle puncture

0%
Microneedle
100%
30G needle
66%
34G needle
More results

We find that microneedles can aspirate ocular cancer cells, both retinoblastoma and uveal melanoma, in vitro and retain a high level of cell viability, 72.83% (49G) compared to 97.00% (25G vitrector) in UM 92-1.

“
Conclusion

A microinvasive approach to biopsy intraocular specimens is feasible, warranting further in vivo studies.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Cross-sectional
44.1%
had too much homocysteine in the blood, a far larger share than in dry AMD or healthy eyes
Cohort Study
92.3%
most laser-treated eyes had a favorable eye-structure outcome
Cohort Study
56%
lost three or more lines on the eye-chart vision test
Cohort Study
50%
older patients were more likely to lose three or more lines of vision
Study
81%
trials where mask air leaks were detected blowing toward the eyes
Cohort Study
13.5%
Central retinal artery peak blood-flow speed was 13.5% lower in diabetic patients.
Study
379 +/- 156 microm
lower thickness in the central retina, checked with an eye scan
Case Report
9 of 10 eyes
eyes had better measured vision after treatment