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New research · Ophthalmology
Current oncology (Toronto, Ont.) · 15h
Cohort studyCurrent oncology (Toronto, Ont.) · 2025

A Population-Based Study of Sex Differences in Cardiovascular Disease Mortality Among Adults with Ocular Cancer in the United States, 2000-2021.

Duke Appiah, Abdulkader Almosa, Eli Heath … Obadeh Shabaneh
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OphthalmologyCohort study

Male sex associated with more than double cardiovascular death hazard in ocular cancer before age 65.

A Population-Based Study of Sex Differences in Cardiovascular Disease Mortality Among Adults with Ocular Cancer in the United States, 2000-2021.

Duke Appiah … Obadeh Shabaneh
Current oncology (Toronto, Ont.) · 2025
Background

Little is known about the manifestation of cardiovascular diseases (cardiovascular diseases) among individuals with ocular cancer (ocular cancer), a population for whom reports on sex-based differences in survival remain inconsistent.

Methods

We used data from 11,460 adults diagnosed with ocular cancer from 2000 to 2021 who were ≥18 years and were enrolled in the Surveillance, Epidemiology, and End Results program.

n = 11,460 adults
Results

Men diagnosed with ocular cancer before 65 had over double the hazard of cardiovascular death versus women.

HR by subgroup · 95% CI
null = 1
CVD mortality
1.54
OC before 65 years of age
2.15
More results

We evaluated the occurrence of cardiovascular diseases mortality after the diagnosis of ocular cancer in the United States.

We used competing risk models to estimate hazard ratios (HR) and 95% confidence intervals (CI).

About 55% of adults were male, with uveal melanoma being the most common ocular cancer (72.1%).

More results

In models adjusted for sociodemographic and clinico-pathophysiological factors, male adults had elevated risk for cardiovascular diseases mortality (HR: 1.54, 95%CI: 1.31-1.81).

“
Conclusion

Implementation of optimal cardiovascular health interventions after diagnosis of ocular cancer, especially among men, holds promise in enhancing survival in this population.

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