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New research · Ophthalmology
BMJ open ophthalmology · 16h
Cohort studyBMJ open ophthalmology · 2025

Role of additional topotecan injections (plus two) in reducing recurrence rate in retinoblastoma of group D and group E patients: a retrospective study.

Xintong Lin, Zhuqing Zheng, Haifeng Chen … Kang Xue
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OphthalmologyCohort study

Extra topotecan injections after seed regression saved 92.3% of retinoblastoma eyes.

Role of additional topotecan injections (plus two) in reducing recurrence rate in retinoblastoma of group D and group E patients: a retrospective study.

Xintong Lin … Kang Xue
BMJ open ophthalmology · 2025
Purpose

To evaluate the effectiveness of administering additional intravitreal topotecan injections (plus two) in reducing the recurrence rate in patients with advanced retinoblastoma (retinoblastoma).

Methods

This retrospective, non-comparative and interventional study encompassed 26 eyes of 25 patients with retinoblastoma, treated between January 2019 and April 2024.

n = 26 eyes
Results
92.3%
extra injections after seeds cleared saved the eye without removal
n = 26 eyes
More results

The median age of the patients was 26 months, with 57.7% belonging to group D and 42.3% to group E of retinoblastoma classification.

There were no recurrences of vitreous seeds.

No cases of systemic metastasis or death were reported.

“
Conclusion · 1 of 3

Administering additional intravitreal topotecan injections (plus two) following the complete regression of vitreous seeds may contribute to reducing the recurrence rate in patients with retinoblastoma.

Conclusion · 2 of 3

This approach enhances the long-term efficacy of intravitreal injections, thereby contributing to higher eye salvage rates. However, the retrospective, non-randomised design and small sample size remain limitations.

Conclusion · 3 of 3

Multicentre prospective studies are warranted to validate these findings and refine treatment protocols.

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