Implementing ocular treatment with pencil beam scanning: the FHCC experience.

StudyRadiation oncology (London, England)· Nov 2025

Implementing ocular treatment with pencil beam scanning: the FHCC experience.

Jatinder Saini, Andrew Stacey, Alexander Egan … Lia Halasz

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OphthalmologyStudyClinical practiceQ1IF 3.7

Only 16 of 40 ocular proton therapy patients met all treatment planning goals.

Implementing ocular treatment with pencil beam scanning: the FHCC experience.

Jatinder Saini … Lia Halasz

Radiation oncology (London, England) · Nov 2025

Background

The Fred Hutchinson Cancer Center (Fred Hutchinson Cancer Center) has developed a novel in-house method for ocular proton therapy by adapting a pencil beam scanning (pencil beam scanning) beamline and using a commercial treatment planning system.

Methods

Key innovations of our treatment approach include in-house developed treatment chair and gaze localization systems, CT imaging for planning, and a Monte Carlo algorithm for dose calculation.

n = 40 patients

16

Results

16

fewer than half of patients' treatment plans met every dosing goal

n = 40 patients

More results

The average patient age at the time of treatment was 63.9 years.

Tumor apical height ranged from 0.7 to 11.9 mm, and the largest basal diameter from 2.8 to 15.5 mm.

The D99% dose to GTV ranged from 5041 to 5242 cGy (RBE).

More results

The median mean dose to the lacrimal gland was 1570 cGy (RBE), while the median D2% doses to the optic nerve, macula, and optic disc were 4188 cGy (RBE), 5024 cGy (RBE), and 5133 cGy (RBE), respectively.

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Conclusion

The approach at Fred Hutchinson Cancer Center demonstrates that ocular proton therapy can be effectively delivered using a general-purpose pencil beam scanning beamline, providing a solution for centers without dedicated ocular beamlines.

Implementing ocular treatment with pencil beam scanning: the FHCC experience.

Implementing ocular treatment with pencil beam scanning: the FHCC experience.

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