Post

New research · Ophthalmology
Radiation oncology (London, England) · 16h
StudyRadiation oncology (London, England) · 2025

Implementing ocular treatment with pencil beam scanning: the FHCC experience.

Jatinder Saini, Andrew Stacey, Alexander Egan … Lia Halasz
Read paper
OphthalmologyStudy

Only 16 of 40 ocular proton therapy patients met all treatment planning goals.

Implementing ocular treatment with pencil beam scanning: the FHCC experience.

Jatinder Saini … Lia Halasz
Radiation oncology (London, England) · 2025
Background

The Fred Hutchinson Cancer Center (Fred Hutchinson Cancer Center) has developed a novel in-house method for ocular proton therapy by adapting a pencil beam scanning (pencil beam scanning) beamline and using a commercial treatment planning system.

Methods

Key innovations of our treatment approach include in-house developed treatment chair and gaze localization systems, CT imaging for planning, and a Monte Carlo algorithm for dose calculation.

n = 40 patients
16
Results
16
fewer than half of patients' treatment plans met every dosing goal
n = 40 patients
More results

The average patient age at the time of treatment was 63.9 years.

Tumor apical height ranged from 0.7 to 11.9 mm, and the largest basal diameter from 2.8 to 15.5 mm.

The D99% dose to GTV ranged from 5041 to 5242 cGy (RBE).

More results

The median mean dose to the lacrimal gland was 1570 cGy (RBE), while the median D2% doses to the optic nerve, macula, and optic disc were 4188 cGy (RBE), 5024 cGy (RBE), and 5133 cGy (RBE), respectively.

“
Conclusion

The approach at Fred Hutchinson Cancer Center demonstrates that ocular proton therapy can be effectively delivered using a general-purpose pencil beam scanning beamline, providing a solution for centers without dedicated ocular beamlines.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Cross-sectional
44.1%
had too much homocysteine in the blood, a far larger share than in dry AMD or healthy eyes
Cohort Study
92.3%
most laser-treated eyes had a favorable eye-structure outcome
Cohort Study
56%
lost three or more lines on the eye-chart vision test
Cohort Study
50%
older patients were more likely to lose three or more lines of vision
Study
81%
trials where mask air leaks were detected blowing toward the eyes
Cohort Study
13.5%
Central retinal artery peak blood-flow speed was 13.5% lower in diabetic patients.
Study
379 +/- 156 microm
lower thickness in the central retina, checked with an eye scan
Case Report
9 of 10 eyes
eyes had better measured vision after treatment