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Cohort studyEuropean journal of ophthalmology · 2026

Clinical outcomes of pars plana vitrectomy with endoresection in uveal melanoma primarily treated with plaque radiotherapy or proton beam therapy.

Leonoor S Koetsier, Marina Marinkovic, Jaco C Bleeker … Thomas J van Rijssen

OphthalmologyCohort study

After endoresection, visual acuity improved in ruthenium brachytherapy-treated eyes but not proton beam-treated eyes.

Clinical outcomes of pars plana vitrectomy with endoresection in uveal melanoma primarily treated with plaque radiotherapy or proton beam therapy.

Leonoor S Koetsier … Thomas J van Rijssen

European journal of ophthalmology · 2026

Background

To describe the characteristics and outcomes of endoresection in patients with uveal melanoma previously treated with ruthenium brachytherapy or proton beam therapy.

Methods

In this retrospective study, data on the indication to perform endoresection, best-corrected visual acuity, tumor characteristics, surgery details, and characteristics of ruthenium brachytherapy or proton beam therapy were obtained.

n = 27 patients

Results

after this surgery, ruthenium patients' eyesight got better, on average

0.186Snelle

Ruthenium

-0.009Snelle

Proton beam

More results

The indication for endoresection was exudative retinal detachment in 20 patients, glaucoma induced by tumor bleeding in 6 patients, and persistent inflammation in 1 patient.

In the ruthenium group, mean visual acuity before endoresection in Snellen was 0.099 ± 0.197, which increased to 0.285 ± 0.302 after endoresection (p = 0.043).

More results

In the proton beam group, mean visual acuity before endoresection was 0.030 ± 0.044, which decreased to 0.020 ± 0.036 after endoresection (p = 0.546).

Enucleation had to be performed in 1 eye in the ruthenium group and 8 eyes in the proton beam group.

“

Conclusion · 1 of 2

Patients previously treated with ruthenium brachytherapy have favorable post-endoresection outcomes, opposed to those treated with proton beam therapy.

Conclusion · 2 of 2

Patient-specific counselling is important before endoresection, as there is a wide variety in expected outcomes.

Post

Clinical outcomes of pars plana vitrectomy with endoresection in uveal melanoma primarily treated with plaque radiotherapy or proton beam therapy.

After endoresection, visual acuity improved in ruthenium brachytherapy-treated eyes but not proton beam-treated eyes.

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