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New research · Ophthalmology
The British journal of ophthalmology · 16h
Cohort studyThe British journal of ophthalmology · 2026

Severe visual loss and ocular complications after intra-arterial chemotherapy for retinoblastoma.

Carlos Solera-de-Andrés, Paula Spang-Valencia, Jesús Peralta-Calvo
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OphthalmologyCohort study

Most retinoblastoma eyes treated with intra-arterial chemotherapy had severe final visual loss.

Severe visual loss and ocular complications after intra-arterial chemotherapy for retinoblastoma.

Carlos Solera-de-Andrés … Jesús Peralta-Calvo
The British journal of ophthalmology · 2026
Background

Intra-arterial chemotherapy (intra-arterial chemotherapy) has improved globe salvage, but there remains limited information on visual outcomes following this treatment.

Purpose

Retinoblastoma (retinoblastoma) treatment aims to ensure survival, globe preservation and visual function.

Methods

A retrospective review was conducted at La Paz University Hospital in Madrid, including 71 eyes from 60 patients treated with intra-arterial chemotherapy from 2016 to 2025.

n = 71 eyes
Results

85% of eyes with measurable vision scored logMAR ≥1.0, meaning very poor final acuity.

VA≥1.0 logMAR
85.2%
VA<1.0 logMAR
14.8%
More results

Of the 71 eyes, 24 belonged to patients too immature for visual acuity assessment, and 20 were enucleated due to disease progression.

Among the 27 eyes with measurable visual acuity, 7 had a healthy fovea at diagnosis.

Only four eyes (14.8%) achieved a visual acuity<1.0 logMAR, all with a healthy fovea at diagnosis.

More results

16 of 71 eyes (22.5%) developed choroidal occlusive vasculopathy, with statistically significant correlation with the number of intra-arterial chemotherapy cycles.

“
Conclusion · 1 of 2

Intra-arterial chemotherapy is effective for tumour control and eye preservation but often yields poor visual outcomes in advanced retinoblastoma due to pre-existing damage and complications like choroidal occlusive vasculopathy.

Conclusion · 2 of 2

These findings emphasise the importance of counselling families regarding the visual limitations of intra-arterial chemotherapy treatment.

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