Effect of radiation dosage to vital ocular structures on visual outcomes: Re-evaluation for the future.

Cohort studyBrachytherapy· May 2026

Effect of radiation dosage to vital ocular structures on visual outcomes: Re-evaluation for the future.

Lauren B Yeager, Emmanouil Tsamis, Matthew Bompastore … Brian P Marr

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Ocular OncologyCohort studyClinical practiceQ2IF 1.6

Foveal radiation dose under 35 Gy linked to more patients keeping useful vision

Effect of radiation dosage to vital ocular structures on visual outcomes: Re-evaluation for the future.

Lauren B Yeager … Brian P Marr

Brachytherapy · May 2026

Purpose

To explore the impact of radiation dosage on vital ocular structures to identify target dosage for vision preservation in patients with uveal melanoma treated with Eye Physics plaque brachytherapy.

Methods

Retrospective chart review was performed.

>50%

Results

>50%

cutting foveal radiation dose below 35 gy helped more patients keep useful eyesight

More results

One hundred thirty-six patients met inclusion criteria.

Initial visual acuity was 20/20-20/40 in 71%, and ≤20/200 in 7% of patients.

Higher total dose and average dose rate to the optic disc, fovea, lens, opposite retina and sclera were associated with worse visual outcomes.

More results

Foveal dosage <35 Gy resulted in the greatest proportion of patients maintaining useful vision followed by a dose of <27.5 Gy to the optic nerve.

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Conclusion

<35 Gy to the fovea and <27.5 Gy to the optic disc results in >50% of patients maintaining useful vision and may represent dose target values and are important when considering neoadjuvant treatments prior to definitive plaque brachytherapy.

Effect of radiation dosage to vital ocular structures on visual outcomes: Re-evaluation for the future.

Effect of radiation dosage to vital ocular structures on visual outcomes: Re-evaluation for the future.

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