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Cohort studyThe British journal of ophthalmology · 2025

Visual outcomes in retinoblastoma: an analysis of 426 eyes in an Indian cohort.

Abhishek Das, Parag K Shah, Sajini Panthalodi … Narendran Venkatapathy

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OphthalmologyCohort study

Late-stage retinoblastoma tumor groups had far higher rates of visual impairment and blindness.

Visual outcomes in retinoblastoma: an analysis of 426 eyes in an Indian cohort.

Abhishek Das … Narendran Venkatapathy

The British journal of ophthalmology · 2025

Background

Retinoblastoma is the most common intraocular tumour in children.

Purpose

This study aimed to assess the visual outcomes and risk factors leading to visual impairment in children with retinoblastoma in the Indian population.

Methods

This is a single-centre retrospective analysis of all patients with unilateral or bilateral retinoblastoma presenting from the year 2014 to mid-2024.

n = 426 eyes

Results

Share of eyes with impaired or legally blind vision in late-stage groups D and E, significantly higher than earlier stages.

55.18%

Group D

68.18%

Group E

More results

240 (78.43%) had unilateral macular tumours, while 45 (14.71%) had bilateral macular tumours.

Visual impairment and legal blindness were noted in only 27.59% and 0.05% of patients without macular tumours.

Three patients had motor and speech delay.

More results

Out of 120 patients with bilateral tumour, 45 successfully underwent occlusion therapy.

“

Conclusion

Macular involvement and late-stage presentation were major predictors of poor vision. This study underscores the importance of early diagnosis and treatment, and improved access to paediatric vision screening and visual rehabilitation.

Post

Visual outcomes in retinoblastoma: an analysis of 426 eyes in an Indian cohort.

Late-stage retinoblastoma tumor groups had far higher rates of visual impairment and blindness.

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