Topical 5-fluorouracil 1% versus surgical removal as a primary treatment modality for ocular surface squamous neoplasia: a comparison of recurrences and side effects.

There was no statistically significant difference in the recurrence rate between the 5-FU and surgery groups.

Patients were treated a median of 3 cycles (range 1-9) of topical 5-FU eye drops in the 5-FU group.

Treatment-related ocular symptoms were reported in 45.5% (5/11) of patients in the 5-FU group, while a 57.1% (8/14) incidence of side effects in the surgical group.

Limbal stem cell deficiency, symblepharon, and systemic symptoms were not observed in either the 5-FU or surgery groups.