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New research · Ophthalmology
BMC ophthalmology · 16h
Cohort studyBMC ophthalmology · 2025

Topical 5-fluorouracil 1% versus surgical removal as a primary treatment modality for ocular surface squamous neoplasia: a comparison of recurrences and side effects.

Xi Lan, Dongyu Zhang, Shunrong Luo … Zhirong Lin
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OphthalmologyCohort study

Recurrence rate after topical 5-fluorouracil similar to surgery for ocular surface squamous neoplasia.

Topical 5-fluorouracil 1% versus surgical removal as a primary treatment modality for ocular surface squamous neoplasia: a comparison of recurrences and side effects.

Xi Lan … Zhirong Lin
BMC ophthalmology · 2025
Purpose

To compare the efficacy and safety of topical 5-fluorouracil (5-FU) 1% eye drops versus surgical removal as a primary treatment modality for ocular surface squamous neoplasia (ocular surface squamous neoplasia).

Methods

This retrospective cohort study included 11 patients who received 5-FU 1% (5-FU group) and 14 patients who received surgical removal (surgery group) as a primary therapy for ocular surface squamous neoplasia in an ophthalmic hospital from 2018 to 2023.

n = 14 patients
Results

recurrence returned in a similar share of patients with each treatment

5-FU group
18.2%
Surgery group
14.3%
More results

There was no statistically significant difference in the recurrence rate between the 5-FU and surgery groups.

Patients were treated a median of 3 cycles (range 1-9) of topical 5-FU eye drops in the 5-FU group.

More results

Treatment-related ocular symptoms were reported in 45.5% (5/11) of patients in the 5-FU group, while a 57.1% (8/14) incidence of side effects in the surgical group.

Limbal stem cell deficiency, symblepharon, and systemic symptoms were not observed in either the 5-FU or surgery groups.

“
Conclusion · 1 of 2

Both 5-FU and surgical removal are effective and present a good security profile as primary therapies for ocular surface squamous neoplasia.

Conclusion · 2 of 2

The two treatment modalities have no significant difference in the frequency of side effects or the time interval to recurrence.

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