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Cohort studyContemporary oncology (Poznan, Poland) · 2025

Clinical outcomes of fractionated stereotactic radiotherapy for uveal melanoma - a Polish single-centre experience.

Adam Deja, Paulina Baluch, Marta Wróblewska-Zierhoffer … Iwona Rospond-Kubiak

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OphthalmologyCohort study

Fractionated stereotactic radiotherapy controlled uveal melanoma locally in 96.2% of cases.

Clinical outcomes of fractionated stereotactic radiotherapy for uveal melanoma - a Polish single-centre experience.

Adam Deja … Iwona Rospond-Kubiak

Contemporary oncology (Poznan, Poland) · 2025

Background

The aim of the study is to present the results of the first Polish cohort of patients treated with fractionated stereotactic radiotherapy (fSRT) for large and/or juxtapapillary uveal melanoma (uveal melanoma).

Methods

The medical records of the patients who underwent the fSRT for uveal melanoma in Poznań (cooperation between the Department of Ophthalmology, Poznań University of Medical Sciences and Greater Poland Cancer Centre) in 2014-2020 were retrospectively reviewed.

n = 27 patients

Results

96.2%

Local tumor control rate achieved after fSRT treatment in this cohort.

n = 27 patients

More results

We identified 27 patients, 12 men, 15 women, with a median age of 61.5 years.

The median longitudinal basal diameter of treated tumours was 11.7 mm (range 5.2-17.8 mm), median thickness - 7.5 mm (range 1.7-9.7 mm).

We observed neovascular glaucoma in 9 (34%) patients, which was the reason for globe removal in 3 (11%) of them.

More results

There was one local tumour recurrence (3.8%) with extraorbital extension 6 years post-treatment.

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Conclusion

As reported also by other authors, fSRT could be a useful treatment modality for selected large and/or juxtapapillary melanomas.

Post

Clinical outcomes of fractionated stereotactic radiotherapy for uveal melanoma - a Polish single-centre experience.

Fractionated stereotactic radiotherapy controlled uveal melanoma locally in 96.2% of cases.

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