Analysis of prognosis and quality of life in children with retinoblastoma.
Globe-preservation was achieved in about two-thirds of retinoblastoma eyes overall.
Analysis of prognosis and quality of life in children with retinoblastoma.
To evaluate clinical characteristics, treatment patterns and long-term quality of life (quality of life) among children with retinoblastoma (retinoblastoma) managed at a single tertiary center in China.
Totally 62 consecutive patients (71 eyes) diagnosed with retinoblastoma were retrospectively reviewed.
checking eyes, most kept their natural eye instead of removal
Overall survival was 90.32% (56/62), mortality was 9.68% (6/62).
Eye salvage by international intraocular retinoblastoma classification stage was 100% for A-C, 71.43% (15/21) for D, and 36.84% (7/19) for E; no eyes were preserved in extraocular disease.
Compared with the globe-preservation group, enucleated children had significantly lower scores in appearance, social functioning, and role domains on quality of life measures ( P <0.05).
Across all PedEyeQ domains, children with preserved globes scored higher than those who underwent enucleation ( P <0.05).
Most children in this cohort present with intermediate-to-advanced disease, which limit eye-preservation opportunities.
While survival approached contemporary benchmarks, quality of life deficits are most pronounced in appearance, social participation, and role functioning after enucleation.
Additionally, parents of children who underwent enucleation often experience heightened anxiety about their child's vision and social integration.