ScholarDeck

Cohort studyRetinal cases & brief reports · 2026

Treatment of choroidal melanoma-associated exudative retinal detachments with a dexamethasone intravitreal implant prior to proton beam radiation.

Anne Marie Lane, Evangelos S Gragoudas, Ivana K Kim

OphthalmologyCohort study

Dexamethasone implant before proton radiation did not improve retinal detachment resolution in choroidal melanoma

Treatment of choroidal melanoma-associated exudative retinal detachments with a dexamethasone intravitreal implant prior to proton beam radiation.

Anne Marie Lane … Ivana K Kim

Retinal cases & brief reports · 2026

Purpose

To evaluate the safety and potential efficacy of a dexamethasone implant (Ozurdex) administered prior to proton radiation. in patients with tumor-associated exudative retinal detachments.

Methods

Diagnosed with choroidal melanomas ≤10 mm thick, detachments spanning > 2 clock hours, and visual acuity of 20/100 or better were randomized 1:1 to receive the dexamethasone implant or no treatment prior to proton radiation.

n = 5

Results

retinal detachment (fluid under retina) resolved less often with the implant

Dexamethasone

40%

No treatment

80%

More results

Baseline characteristics were similar between the dexamethasone (n=5) and no treatment (n=5) groups; median retinal detachment size was 4 clock hours at presentation in both groups.

“

Conclusion

Improved clinical outcomes were not observed in patients receiving the dexamethasone implant prior to proton radiation. No new safety concerns were identified with the use of dexamethasone in this cohort.

Post

Treatment of choroidal melanoma-associated exudative retinal detachments with a dexamethasone intravitreal implant prior to proton beam radiation.

Dexamethasone implant before proton radiation did not improve retinal detachment resolution in choroidal melanoma

Related papers