Stereotactic Radiosurgery Outcomes in Uveal Melanoma Patients: A 3-year Retrospective Study.

Cohort studyCeska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti· 2026

Stereotactic Radiosurgery Outcomes in Uveal Melanoma Patients: A 3-year Retrospective Study.

Jozef Sklenka, Pavla Horňáčková, Daniela Vysloužilová … Oldřich Chrapek

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Ocular OncologyCohort studyTreatmentQ3IF 0.5

Local tumor control at 3 years reached only 75.8% after stereotactic radiosurgery.

Stereotactic Radiosurgery Outcomes in Uveal Melanoma Patients: A 3-year Retrospective Study.

Jozef Sklenka … Oldřich Chrapek

Ceska a slovenska oftalmologie · 2026 · Q3 in Ophthalmology

Purpose

To evaluate the three-year survival rate, local tumor control rate and complications of stereotactic radiosurgery in patients with uveal melanoma and compare the outcomes with the available literature.

Methods

In this study, data were evaluated from 122 patients treated for uveal melanoma, of whom 33 met the inclusion criteria for retrospective analysis of stereotactic radiosurgery outcomes using the CyberKnife system.

n = 122 patients

Results

only about 3 in 4 tumors were still controlled at 3 years

Eye preservation

72.7%

Local tumor control

75.8%

Survival

81.8%

More results

The three-year survival was 81.8%.

Overall, metastases were detected in 30.3% of patients with the liver being affected in 44% of cases, the bones in 28%, and the lungs in 17%.

More results

The most common ocular complications of radiotherapy included cataracts (58.3% of phakic patients), neovascular glaucoma (39.4%), radiation maculopathy (27.3%) and radiation retinopathy (18.2%).

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Conclusion · 1 of 3

Stereotactic radiosurgery is a safe treatment method for uveal melanoma with the potential for eye preservation. However, it carries the risk of tumor recurrence and ocular complications.

Conclusion · 2 of 3

Three-year survival and the incidence of ocular complications in our study were consistent with the data reported in the literature. By contrast, three-year local tumor control reached lower values compared to the relevant studies.

Conclusion · 3 of 3

Some results may be limited due to the small number of subjects in our cohort.

Stereotactic Radiosurgery Outcomes in Uveal Melanoma Patients: A 3-year Retrospective Study.

Stereotactic Radiosurgery Outcomes in Uveal Melanoma Patients: A 3-year Retrospective Study.

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