Low dose iodine-125 brachytherapy and transpupillary thermal therapy for small- to medium-sized choroidal… | ScholarDeck

Paper

Low dose iodine-125 brachytherapy and transpupillary thermal therapy for small- to medium-sized choroidal melanoma.

New research · Ophthalmology

Brachytherapy · 1mo

Cohort studyBrachytherapy· Mar 2026

Low dose iodine-125 brachytherapy and transpupillary thermal therapy for small- to medium-sized choroidal melanoma.

S Fattahi, C L Deufel, K V Astafurov … K S Corbin

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Ocular OncologyCohort studyTreatmentQ2IF 1.6

Reduced-dose iodine-125 brachytherapy gave 0% local tumor recurrence at 5 years.

Low dose iodine-125 brachytherapy and transpupillary thermal therapy for small- to medium-sized choroidal melanoma.

S Fattahi … K S Corbin

Brachytherapy · Mar 2026

Purpose

COMS established iodine-125 ( 125 I) brachytherapy as standard of care for medium-sized choroidal melanomas.

Methods

Diagnosed 2005-2019 with choroidal melanoma <5 mm thick and managed with 125 I brachytherapy dose of 65 Gy to depth of 5 mm were included.

n = 143 patients

Results

no tumors regrew locally within 5 years of treatment

n = 143 patients

More results

Five-year Kaplan-Meier estimates of ocular adverse events were 59.6% radiation maculopathy, 42.0% cystoid macular edema, 55.2% nonproliferative radiation retinopathy, 10.8% proliferative radiation retinopathy, and 35.6% radiation papillopathy.

“

Conclusion

Reduced dose 125 I brachytherapy is feasible with excellent local tumor control.

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