Comparative efficacy and safety of ab-interno XEN 45 gel implantation versus trabeculectomy for glaucoma: a systematic review and meta-analysis.

No significant difference was observed in the number of antiglaucoma medications (MD: -0.03 (95% CI: -0.23 to 0.18); I 2 = 53%).

Rates of hyphema, choroidal detachment, hypotony, flat anterior chamber, bleb revision, and reoperation showed no statistically significant differences between procedures, although substantial heterogeneity was observed for hyphema ( I 2 = 60%), hypotony ( I 2 = 76%), and reoperation ( I 2 = 53%).