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New research · Ophthalmology
Journal of clinical medicine · 18h
ReviewJournal of clinical medicine · 2026

Real-World Outcomes of Switching to Aflibercept 8 mg in Previously Treated Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis.

Abdullah Bousamri, Mohammad Kana'an, Faisal Alharbi, Noor Alqudah
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OphthalmologyReview

Switching to aflibercept 8 mg was linked to reduced retinal thickness in previously treated eyes.

Real-World Outcomes of Switching to Aflibercept 8 mg in Previously Treated Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis.

Abdullah Bousamri … Noor Alqudah
Journal of clinical medicine · 2026
Background

Neovascular age-related macular degeneration (nAMD) remains a leading cause of irreversible central vision loss.

Methods

Following PRISMA 2020 guidelines, we searched PubMed, Embase, Web of Science, CENTRAL, Scopus, and Google Scholar through April 2026.

Results

eye scans showed less retinal swelling after switching

WMD -21.50 (95% CI -29.30 to -13.70)
null = 0-29.30-13.70
CI excludes the null - significant
More results

Twenty-one studies met inclusion criteria.

BCVA remained stable (WMD: -0.017 logMAR; 95% CI: -0.027 to -0.007; +0.83 ETDRS letters; I 2 = 0%).

Intraretinal and subretinal fluid each resolved in 37.5% of eyes.

More results

Intraocular inflammation was rare across 9959 treated eyes, though this pool was not restricted to switched eyes, with no confirmed retinal vasculitis.

“
Conclusion · 1 of 2

Low-certainty evidence suggests that switching to aflibercept 8 mg preserves visual acuity, while very-low-certainty evidence suggests reductions in central subfield thickness and modest extension of treatment intervals.

Conclusion · 2 of 2

Intraocular inflammation was rare, though safety denominators included non-switch eyes. These findings provide preliminary pooled estimates to inform switch decisions in previously treated eyes.

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