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New research · Ophthalmology
International ophthalmology · 18h
Cohort studyInternational ophthalmology · 2026

Uveitis-glaucoma-hyphema syndrome after secondary intraocular lens implantation: incidence and clinical features in a real-world cohort.

Francisco Calleja-Casado, Noemí Ruiz Del Río, Francisca García-Ibor … Antonio Duch Samper
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OphthalmologyCohort study

Uveitis-glaucoma-hyphema syndrome risk was far higher with scleral-sutured than iris-claw lens fixation

Uveitis-glaucoma-hyphema syndrome after secondary intraocular lens implantation: incidence and clinical features in a real-world cohort.

Francisco Calleja-Casado … Antonio Duch Samper
International ophthalmology · 2026
Purpose

To evaluate the incidence and clinical characteristics of uveitis-glaucoma-hyphema (uveitis-glaucoma-hyphema) syndrome after secondary intraocular lens (intraocular lens) implantation and to assess its distribution according to fixation approach.

Methods

This retrospective cohort study included patients undergoing secondary intraocular lens implantation without capsular support between May 2018 and February 2025 at a tertiary referral centre.

n = 1446 eyes
Results

scleral-sutured lenses raised risk of this eye complication far more than iris-claw lenses

RR 8 (95% CI 1.90 to 33.30)
null 1
1.90
33.30
CI excludes the null - significant
More results

Uveitis-glaucoma-hyphema developed in 14 of 77 eyes (18.2%).

No eye suffered permanent vision loss directly attributable to uveitis-glaucoma-hyphema syndrome.

Thirteen of 14 cases occurred in left eyes.

“
Conclusion · 1 of 2

In this real-world cohort, uveitis-glaucoma-hyphema occurred predominantly in anatomically high-risk eyes undergoing scleral-sutured fixation.

Conclusion · 2 of 2

These findings suggest a potential interaction between baseline ocular vulnerability and fixation technique, underscoring the importance of individualized surgical planning and postoperative monitoring.

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