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New research · Ophthalmology
Radiation oncology (London, England) · 18h
Cohort studyRadiation oncology (London, England) · 2026

Hypofractionated stereotactic radiation therapy for optic nerve sheath meningiomas: A single-center experience and preliminary results.

YuanYou Yang, FengXia Luo, Chao Wang … Yi Wang
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OphthalmologyCohort study

Hypofractionated stereotactic radiotherapy preserved vision in only 30.2% of patients with optic nerve sheath meningioma.

Hypofractionated stereotactic radiation therapy for optic nerve sheath meningiomas: A single-center experience and preliminary results.

YuanYou Yang … Yi Wang
Radiation oncology (London, England) · 2026
Background

Primary optic nerve sheath meningioma (pONSM) causes progressive vision loss.

Methods

This retrospective STROBE-compliant study (2016-2023) included imaging-confirmed ONSM patients (PS 0-2) unsuitable for or refusing surgery/CFRT.

n = 43 patients
30.2%
Results
30.2%
vision was kept from worsening in fewer than 1 in 3 patients
n = 43 patients
More results

Preservation rates by baseline status: normal 40% (4/10), mild loss 63.6% (7/11), moderate loss 12.5% (1/8), severe loss 7.1% (1/14).

Acute toxicity: reversible ocular pain (16.3%), eyelid edema (13.9%); late retinal hemorrhage (7.0%).

Time to blindness was shorter with moderate/severe vs. normal/mild baseline loss (p < 0.001).

More results

All acute cases were in normal/mild baseline subgroup (preservation: 75.0% and 80.0%, respectively).

“
Conclusion · 1 of 2

Hypo-FSRT yielded 100% tumor control and 76.7% regression, but lower vision preservation (30.2%) than CFRT, particularly with moderate/severe baseline loss. Acute impairment (≤ 2 months) predicts better preservation.

Conclusion · 2 of 2

Low preservation with normal baseline vision necessitates individualized planning balancing tumor control, vision, and cosmesis. CFRT preferred for vision preservation; optimal fractionation needs prospective validation.

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