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New research · Ophthalmology
Frontiers in endocrinology · 23h
Cohort studyFrontiers in endocrinology · 2026

A FAERS database study on visual impairment adverse events associated with three long-acting insulin analogues.

Li Zhong, Wenxuan Cao, Xinyu Liu … Jing Yan
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OphthalmologyCohort study

Insulin glargine had the strongest link to visual impairment reports among long-acting insulins.

A FAERS database study on visual impairment adverse events associated with three long-acting insulin analogues.

Li Zhong … Jing Yan
Frontiers in endocrinology · 2026
Purpose

To utilize the U.

Methods

This retrospective pharmacovigilance study analyzed FAERS data from Q1 2004 to Q2 2025.

n = 102,953 primary suspect reports
Results

insulin glargine linked to far more visual-impairment reports than other insulins

ROR 3.60 (95% CI 3.54 to 3.67)
null = 03.543.67
CI excludes the null - significant
More results

Statistically significant visual impairment signals were detected across all three insulins.

Among the 5,780 specific "visual impairment" reports, over 60% involved female patients, and 93% originated from the United States.

More results

Multivariate regression suggested that higher body weight might be a potential protective factor (P < 0.05); however, this finding may be confounded by the database's inherent limitation in differentiating between Type 1 and Type 2 diabetes characteristics.

“
Conclusion · 1 of 3

Long-acting insulins are associated with varying risks of visual impairment adverse events, exhibiting an early-onset temporal pattern.

Conclusion · 2 of 3

Insulin glargine demonstrated stronger disproportionality signals for glaucoma, while degludec and detemir were more closely associated with retinopathy.

Conclusion · 3 of 3

These characteristics suggest the necessity of implementing individualized ophthalmic monitoring during the early phase of initiating basal insulin therapy in diabetic patients.

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