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New research · Ophthalmology
PLOS global public health · 23h
Meta-analysisPLOS global public health · 2026

Diagnostic test accuracy of teleretinal screening for cytomegalovirus retinitis among people living with HIV: A systematic review and meta-analysis.

Holijah Uy, Leandrea Nollora, Matthew Villanueva … Albert John Bromeo
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OphthalmologyMeta-analysis

Teleretinal screening detects cytomegalovirus retinitis in HIV patients with high specificity.

Diagnostic test accuracy of teleretinal screening for cytomegalovirus retinitis among people living with HIV: A systematic review and meta-analysis.

Holijah Uy … Albert John Bromeo
PLOS global public health · 2026
Background

Cytomegalovirus retinitis (cytomegalovirus retinitis) remains a major cause of preventable blindness among people living with human immunodeficiency virus (people living with human immunodeficiency virus), particularly in resource-limited settings where access to ophthalmologists is constrained.

Purpose

This review aimed to determine the diagnostic accuracy of teleretinal screening for cytomegalovirus retinitis in people living with human immunodeficiency virus.

Methods

It was conducted in accordance with the PRISMA diagnostic test accuracy guidelines and was registered prospectively in PROSPERO (CRD420250637110).

n = 1,460 eyes
Results

means CMV eye infection was correctly ruled out when truly absent

87.11%
Sensitivity
97.73%
Specificity
More results

The Cochrane Library, PubMed, CINAHL, Scopus, and Web of Science were searched on March 1, 2025.

Subgroup analyses suggested higher sensitivity among populations with lower CD4 cell count thresholds.

Sensitivity analysis showed no significant changes after excluding studies with a high risk of bias.

More results

Nonetheless, further high-quality studies in diverse lower-resource settings are needed to strengthen the evidence base and guide scalable implementation within HIV care systems.

“
Conclusion

It was conducted in accordance with the PRISMA diagnostic test accuracy guidelines and was registered prospectively

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