Lacrimal gland ocular melanoma had the highest mortality of any primary site studied.
Prognostic Biomarkers of Survival in Ocular Melanoma.
Christina N Bobrek … Majda Hadziahmetovic
Ophthalmic epidemiology · 2026
Purpose
To explore the Surveillance, Epidemiology, and End Results Program (SEER) database in a longitudinal study to determine the factors associated with the risk of death in ocular melanoma.
Methods
With a primary diagnosis of ocular melanoma from the SEER database between 1975 and 2022 were included.
n = 2,917 included patients
Results
every lacrimal gland melanoma patient studied died of the disease
OR 0.98 (95% CI 0.98 to 0.99)
null 1
0.98
0.99
CI excludes the null - significant
More results
Survival analysis with Kaplan-Meier estimate showed lacrimal gland and overlapping lesions of eye and adnexa differed in mean months of survival after diagnosis (54 months and 100.8 months, respectively) compared to conjunctiva and ciliary body (264.5 months and 237.5 months, respectively; p < 0.001).
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Conclusion
Age and primary site were associated with mortality from ocular melanoma. Overlapping lesions of the eye and adnexa, unspecified ocular site, and choroid were associated with the highest mortality risk from this melanoma.