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New research · Ophthalmology
American journal of ophthalmology · 23h
Cohort studyAmerican journal of ophthalmology · 2026

Limited Independent Impact of Maternal Age on Early Childhood Ophthalmic Morbidity: A Nationwide Population-Based Cohort Study.

Seongsu Kang, Sangseok Lee, Geun U Park … Yuri Seo
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OphthalmologyCohort study

In term infants, older maternal age was linked to slightly lower risk of childhood eye disorders

Limited Independent Impact of Maternal Age on Early Childhood Ophthalmic Morbidity: A Nationwide Population-Based Cohort Study.

Seongsu Kang … Yuri Seo
American journal of ophthalmology · 2026
Purpose

To evaluate the independent effect of advanced maternal age (advanced maternal age) on pediatric ophthalmic morbidity, invasive interventions, and healthcare costs.

Methods

Nationwide, population-based cohort study PARTICIPANTS: A total of 2,500,044 mother-infant pairs from a national health insurance database, followed from birth to 5 years of age.

Results

checking eye health, older mothers' babies had slightly lower risk

HR 1.33 (95% CI 1.21 to 1.45)
null = 11.211.45
CI excludes the null - significant
More results

However, this did not translate into reductions in invasive procedures or hospitalization rates.

In contrast, Preterm/LBW status was the primary driver of all ophthalmic risks (HRs 1.52-1.81) and procedures (incidence rate ratios 1.84-2.00) regardless of maternal age.

More results

Among term/NBW infants, higher retinopathy of prematurity diagnosis rates observed in the advanced maternal age group (adjusted HR 1.331; 95% CI, 1.211-1.450) were not accompanied by increased retinopathy of prematurity-related invasive treatment.

“
Conclusion · 1 of 3

Advanced maternal age is not an independent biological determinant of early pediatric ophthalmic disease or treatment-requiring morbidity.

Conclusion · 2 of 3

In the absence of prematurity or low birth weight, children born to older mothers are not at increased risk of early ophthalmic disorders.

Conclusion · 3 of 3

These findings provide evidence-based reassurance for older mothers and support counseling that emphasizes perinatal health status rather than maternal age itself.

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