Anesthesia exposure in unilateral retinoblastoma-comparison of enucleation and intraarterial chemotherapy.

Cohort studyJournal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus· Jun 2026

Anesthesia exposure in unilateral retinoblastoma-comparison of enucleation and intraarterial chemotherapy.

Aurora Rodriguez, Cathrine Ha, Todd Abruzzo, Aparna Ramasubramanian

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Ocular OncologyCohort studyTreatmentQ2IF 1.0

Retinoblastoma treated with intraarterial chemotherapy needed far more anesthesia time than enucleation

Anesthesia exposure in unilateral retinoblastoma-comparison of enucleation and intraarterial chemotherapy.

Aurora Rodriguez … Aparna Ramasubramanian

Journal of AAPOS · Jun 2026 · Q2 in Ophthalmology

Background

Retinoblastoma treatment requires prolonged and repeated exposure to general anesthesia.

Purpose

The purpose of this study was to compare the mean anesthesia exposure time associated with enucleation compared with intraarterial chemotherapy (intraarterial chemotherapy) in patients treated for advanced unilateral retinoblastoma.

Methods

This retrospective study evaluated demographics, tumor features, and treatment details of unilateral intraocular retinoblastoma cases newly diagnosed at a single tertiary care children's hospital between August 2011 and March 2021.

n = 25 patients

2,572

Results

2,572

minutes

anesthesia time was far longer with chemotherapy than with eye removal

n = 25 patients

More results

A total of 25 patients (mean age at diagnosis, 26.4 months) met inclusion criteria (13 primary enucleation and 12 primary intraarterial chemotherapy), undergoing 212 tumor-directed procedures under general anesthesia.

No anesthetic complications were noted in either group.

“

Conclusion

In our small patient cohort, the mean total anesthesia exposure for unilateral retinoblastoma was shorter with enucleation than with intraarterial chemotherapy.

Anesthesia exposure in unilateral retinoblastoma-comparison of enucleation and intraarterial chemotherapy.

Anesthesia exposure in unilateral retinoblastoma-comparison of enucleation and intraarterial chemotherapy.

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