Clinical and multimodal imaging features of ocular syphilis with posterior segment involvement: a 10-case series.

In patients presenting with ocular syphilis as the initial manifestation, ASPPC is the most common posterior segment lesion. Multimodal imaging provides critical diagnostic clues.

Despite frequent initial misdiagnosis, prompt penicillin therapy yields favorable visual outcomes. Routine syphilis serology screening is strongly recommended for any patient with unexplained posterior uveitis or optic neuropathy.