Assessing Optic Nerve Involvement in Multiple Sclerosis Using Optical Coherence Tomography and Magnetic Resonance Imaging.

MRI identified lesions in 46% of patients without a prior history of optic neuritis, whereas OCT-IED was positive in 40%, resulting in an overall OCT-MRI concordance of 77%.

Among asymptomatic patients (n = 164), 25 were Optical Coherence Tomography-negative/MRI-positive (11 with bilateral optic nerve involvement) and 15 were Optical Coherence Tomography-positive/MRI-negative, mostly with isolated ganglion-cell-inner-plexiform-layer or RNFL asymmetry.