Clinical and Demographic Predictors of Optic Neuritis Subtype.

Cohort studyNeuro-ophthalmology (Aeolus Press)· 2026

Clinical and Demographic Predictors of Optic Neuritis Subtype.

Noreen F Khan, Etienne Benard-Seguin, Derek Waldner … Lindsey B De Lott

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Neuro-ophthalmologyCohort studyDiagnosisQ3IF 0.8

Bilateral simultaneous optic neuritis strongly associated with atypical optic neuritis.

Clinical and Demographic Predictors of Optic Neuritis Subtype.

Noreen F Khan … Lindsey B De Lott

Neuro-ophthalmology (Aeolus Press) · 2026 · Q3 in Ophthalmology

Purpose

To determine which clinical features differentiate acute optic neuritis (optic neuritis) subtypes to support treatment decision-making in patients when the diagnostic work-up is incomplete or inconclusive.

Methods

We performed a retrospective study at two academic centers.

n = 518 patients

Results

eyes affected together sharply raises odds of the rarer, atypical type

OR by subgroup · 95% CI

More results

Sensitivity analyses examined the impact of incomplete race/ethnicity data on subtype.

Among 614 episodes (518 patients), most optic neuritis events ( n = 440, 85%) were I/MS-optic neuritis.

More results

In univariate analyses, bilaterality (OR 6.67 [95%CI 3.7,11.11]), presence of optic disc edema (OR 2.22 [95%CI 1.32,3.70]), and age (OR 1.32 [95%CI 1.08,1.61] for each decade) were significantly associated with higher odds of having non-I/MS-ON compared to I/MS-ON.

In sensitivity analyses, age no longer significantly predicted optic neuritis subtype.

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Conclusion

These observations may guide decision-making in patients with optic neuritis, in which diagnostic testing is incomplete or inconclusive.

Clinical and Demographic Predictors of Optic Neuritis Subtype.

Clinical and Demographic Predictors of Optic Neuritis Subtype.

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