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Cohort studyJournal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2026

Six-Month Visual Outcomes in Pediatric Optic Neuritis: A Multicenter Study From South Korea.

Hye Jun Joo, Jae Ryong Song, Byung Chan Lim … Seong-Joon Kim

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OphthalmologyCohort study

Vision recovers substantially by six months in pediatric optic neuritis

Six-Month Visual Outcomes in Pediatric Optic Neuritis: A Multicenter Study From South Korea.

Hye Jun Joo … Seong-Joon Kim

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2026

Background

Current knowledge regarding the causes, clinical course, treatment response, and long-term outcomes of pediatric optic neuritis remains largely derived from case reports and retrospective series.

Purpose

The aim of this study was to provide insights into the etiology and clinical findings of pediatric optic neuritis, thereby improving our knowledge of the condition in the era of antibody-based approaches.

Methods

Younger than 18 years with first-episode optic neuritis were included.

n = 30

Results

at 6 months, vision was close to normal on the eye chart test

Enrolment

0.99logMAR

6 months

0.24logMAR

More results

Bilateral optic neuritis and optic disc swelling were observed in 56.8% and 81.8% of patients, respectively.

The final 6-month diagnoses included myelin oligodendrocyte glycoprotein antibody-associated disease (n = 30 [68.2%]), isolated optic neuritis (n = 11 [25.0%]), acute disseminated encephalomyelitis (n = 2 [4.5%]), multiple sclerosis (n = 1 [2.3%]).

More results

At the 6-month follow-up, 50.0% showed improvement in the visual category, 50.0% maintained their visual category, and none experienced deterioration.

There were no significant predictors related to poor BCVA at enrolment and at 6 months.

“

Conclusion · 1 of 2

Pediatric optic neuritis exhibits severe visual deficits but shows good recovery. Myelin oligodendrocyte glycoprotein antibody-associated disease is the most common etiology.

Conclusion · 2 of 2

These findings reflect the distinct characteristics of pediatric optic neuritis and provide important baseline data for developing tailored treatment strategies.

Post

Six-Month Visual Outcomes in Pediatric Optic Neuritis: A Multicenter Study From South Korea.

Vision recovers substantially by six months in pediatric optic neuritis

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