Neuro-Behçet's disease: Clinical spectrum, management, and outcomes from an Indian cohort.

Cohort studyJournal of neuroimmunology· May 2026

Neuro-Behçet's disease: Clinical spectrum, management, and outcomes from an Indian cohort.

Prachi Mohapatra, Divyani Garg, Ajay Garg … Ayush Agarwal

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Neuro-ophthalmologyCohort studyQ2IF 3.1

Movement disorders in neuro-Behçet's disease were strongly linked to brainstem involvement.

Neuro-Behçet's disease: Clinical spectrum, management, and outcomes from an Indian cohort.

Prachi Mohapatra … Ayush Agarwal

Journal of neuroimmunology · May 2026

Background

Neuro-Behçet's disease (NBD) is a severe neurological manifestation of Behçet's disease.

Methods

We conducted a retrospective chart and neuroimaging review of NBD patients evaluated at a tertiary care referral centre in India between January 2021 and October 2025.

n = 9 patients

Results

in all with brainstem damage vs 1 in 4 without, had movement problems

With brainstem involve

100%

Without brainstem invo

25%

More results

Neurological-onset disease occurred in 9 patients (75.0%).

Ten patients (83.3%) had probable NBD, and two (16.7%) had definite NBD.

Parenchymal disease predominated (9, 75%), with brainstem involvement in 9 patients (75%).

More results

Cerebrospinal fluid (cerebrospinal fluid) showed inflammatory changes, with cerebrospinal fluid-restricted oligoclonal bands detected in one patient (8.3%).

“

Conclusion

NBD in this Indian cohort closely mirrored global disease patterns. Movement disorders, particularly ataxia, are frequent and strongly associated with brainstem involvement, highlighting an under-recognized dimension of parenchymal NBD.

Neuro-Behçet's disease: Clinical spectrum, management, and outcomes from an Indian cohort.

Neuro-Behçet's disease: Clinical spectrum, management, and outcomes from an Indian cohort.

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