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New research · Ophthalmology
AJNR. American journal of neuroradiology · 1d
Cohort studyAJNR. American journal of neuroradiology · 2026

Assessing optic nerve integrity in optic neuritis with conventional magnetic resonance imaging.

Helena Sánchez-Ulloa, Neus Mongay-Ochoa, Manel Alberich … Jaume Sastre-Garriga
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OphthalmologyCohort study

MRI-based inter-eye signal asymmetry detects optic nerve lesions in optic neuritis

Assessing optic nerve integrity in optic neuritis with conventional magnetic resonance imaging.

Helena Sánchez-Ulloa … Jaume Sastre-Garriga
AJNR. American journal of neuroradiology · 2026
Background

The aim of this study was to investigate the integrity of the optic nerve using the ratio between T1WI and T2WI (T1/T2) MRI signal intensities, and to assess whether inter-eye differences could indicate the presence of lesions in the optic nerve.

Methods

The cohort included eighteen healthy controls and forty-nine individuals with multiple sclerosis; from those, thirty-two had a previous episode of optic neuritis.

Results

eye-detection accuracy from brain scan differences was good, correctly flagging most damaged nerves

0.61T1/T2
Lesion
0.74T1/T2
MS without ON
0.77T1/T2
Healthy
More results

Automated masks showed a moderate agreement with the reference segmentations (mean Dice coefficient ± SD = 0.53 ± 0.12).

Eyes with a visible lesion on MRI showed a significantly lower T1/T2 (mean ± SD = 0.61 ± 0.09) compared to other groups (multiple sclerosis without optic neuritis 0.74 ± 0.06, p<0.001; and healthy subjects 0.77 ± 0.09, p<0.001).

“
Conclusion

The findings indicate that conventional MRI can provide clinically meaningful information regarding optic nerve integrity and support the development of automated tools for detecting optic nerve lesions.

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