Clinical features, imaging findings, and treatment outcomes of optic neuritis associated with anti-CRMP5 antibodies: a systematic review.

Median age was 67 years (60-71); 87.1% of patients had clinically symptomatic bilateral optic neuritis, with 64% having a visual acuity worse than 20/200 and ocular pain was uncommon (4.2%).

An associated malignancy was identified in 90.6% of cases, most commonly small-cell lung carcinoma (more than 70%) and breast (5%).

Optic disc edema occurred in 83.9%, frequently with vitreous (70.8%) and retinal (35%) inflammation.

Orbit MRI was normal in 57.1% of cases, but CSF almost universally showed pleocytosis.