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New research · Ophthalmology
Journal of optometry · 1d
Cross-sectionalJournal of optometry · 2026

Validity of optical coherence tomography angiography in the differential diagnosis of papilledema and pseudopapilledema.

Esther Cerdan-Hernandez, María José Palencia-Herranz, Manuel Barón … Pablo Gili
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OphthalmologyCross-sectional

Optical coherence tomography angiography shows higher peripapillary blood vessel density in papilledema than pseudopapilledema.

Validity of optical coherence tomography angiography in the differential diagnosis of papilledema and pseudopapilledema.

Esther Cerdan-Hernandez … Pablo Gili
Journal of optometry · 2026
Purpose

To assess the value of optical coherence tomography angiography (optical coherence tomography angiography) peripapillary retinal vascularization in differentiating papilledema from pseudopapilledema.

Methods

A cross-sectional study, prospective recruitment patients diagnosed with papilledema and pseudopapilledema between January 2021 and December 2022.

n = 95 eyes
Results

Optical coherence tomography angiography scans showed more blood flow around the optic nerve in papilledema

Papilledema
44.377%
Pseudopapilledema
42.46%
More results

Significant differences were found for flux index in the nasal sector (p = 0.034).

Mean vascular flux index had an AUC of 0.683 (95% CI, 0.518-0.848), with 76.9% sensitivity and 58.8% specificity, with a cut-off of 0.461.

More results

Mean perfusion had an AUC of 0.665 (95% CI 0.492-0.838), with 53.8% sensitivity and 76.5% specificity, with a cut-off of 44.25%.

“
Conclusion · 1 of 2

Optical coherence tomography angiography displayed higher peripapillary flux index and perfusion in papilledema than pseudopapilledema in the nasal region.

Conclusion · 2 of 2

These parameters showed moderate diagnostic accuracy and may serve as adjunctive tools in the differential diagnosis of optic disc swelling.

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