Serological biomarkers of JIA-associated uveitis: ANA titers, ANA AC-30 staining pattern and prefoldin 5…

Cohort studyArthritis research & therapy· May 2026

Serological biomarkers of JIA-associated uveitis: ANA titers, ANA AC-30 staining pattern and prefoldin 5 antibodies.

Heinrike Schmeling, Jens Klotsche, Babatope O Adebiyi … Kirsten Minden

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UveitisCohort studyDiagnosisQ1IF 5.1

A specific antinuclear antibody staining pattern (AC-30) is linked to uveitis in juvenile arthritis.

Serological biomarkers of JIA-associated uveitis: ANA titers, ANA AC-30 staining pattern and prefoldin 5 antibodies.

Heinrike Schmeling … Kirsten Minden

Arthritis research & therapy · May 2026

Purpose

To identify serum biomarkers associated with the development of uveitis in a German juvenile idiopathic arthritis (juvenile idiopathic arthritis) cohort.

Methods

A convenience sample, enriched for uveitis cases, was drawn from a prospectively followed inception cohort of newly diagnosed juvenile idiopathic arthritis patients (ICON).

n = 141 patients

Results

positive AC-30 staining pattern was far more common in uveitis patients

63.5%

AC-30 pattern (uveitis

23.4%

AC-30 pattern (no uvei

More results

At first uveitis documentation, 26% of patients presented with uveitis-related complications.

In contrast, the AC-4 indirect immunofluorescence staining pattern was more often present in children without uveitis.

More results

Other tested autoantibodies, including anti-histone antibodies, were rare in both groups and did not differ significantly.

“

Conclusion · 1 of 3

High ANA titers, the AC-30 ANA indirect immunofluorescence (indirect immunofluorescence) pattern, and younger age at juvenile idiopathic arthritis onset are significantly associated with uveitis in juvenile idiopathic arthritis.

Conclusion · 2 of 3

Anti-PFDN5 antibodies show potential as a novel biomarker for juvenile idiopathic arthritis-associated uveitis.

Conclusion · 3 of 3

Combining these serological markers with clinical risk factors may improve early identification of high-risk patients and support the development of better tailored screening strategies to prevent vision-threatening complications.

Serological biomarkers of JIA-associated uveitis: ANA titers, ANA AC-30 staining pattern and prefoldin 5 antibodies.

Serological biomarkers of JIA-associated uveitis: ANA titers, ANA AC-30 staining pattern and prefoldin 5 antibodies.

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