Immune-Mediated Inflammatory Diseases Following Pediatric Uveitis Diagnosis.
Children with uveitis had about 7-fold higher risk of immune-mediated inflammatory diseases
Immune-Mediated Inflammatory Diseases Following Pediatric Uveitis Diagnosis.
IMPORTANCE: Pediatric uveitis is frequently associated with immune-mediated inflammatory diseases (immune-mediated inflammatory diseases); however, population-level estimates of immune-mediated inflammatory diseases risk and immunosuppressant use are limited, as existing evidence is largely derived from tertiary-center cohorts with substantial referral bias.
To estimate the incidence and risk of developing immune-mediated inflammatory diseases among children and adolescents newly diagnosed with noninfectious uveitis without a prior history of immune-mediated inflammatory diseases.
DESIGN, SETTING, AND PARTICIPANTS: This population-based cohort study includes nationwide health insurance claims data from Korea from January 2008 through February 2024.
children with uveitis were about 7 times more likely to develop these diseases than other children
In this cohort study, 27 656 children and adolescents (mean [SD] age, 12.6 [4.8] years; 16 827 males [58.3%]) with incident noninfectious uveitis and no prior immune-mediated inflammatory diseases diagnosis or immunosuppressant prescription were identified.
The estimated 5-year cumulative incidence of composite immune-mediated inflammatory diseases was 8.52% (95% CI, 8.16%-8.87%).
In this cohort study, children and adolescents with uveitis had an approximately 7-fold increased risk of developing immune-mediated inflammatory diseases compared with the general population, with variation in disease patterns and treatment according to demographic and health care factors.
These findings highlight the importance of systematic and risk-stratified screening for immune-mediated inflammatory diseases in pediatric patients with uveitis.