ScholarDeck

Cohort studyFrontiers in cellular and infection microbiology · 2026

Twelve-month functional and structural outcomes of Candida endogenous endophthalmitis in immunocompetent patients: a longitudinal cohort study of an outbreak.

Xiaohan Zhang, Jinfeng Zhang, Xuesong Lin

OphthalmologyCohort study

Chorioretinal Candida eye infection was linked to abnormal new blood vessel growth in all eyes.

Twelve-month functional and structural outcomes of Candida endogenous endophthalmitis in immunocompetent patients: a longitudinal cohort study of an outbreak.

Xiaohan Zhang … Xuesong Lin

Frontiers in cellular and infection microbiology · 2026

Background

To characterize twelve-month visual outcomes, structural complications, and retinal pigment epithelium (retinal pigment epithelium) dynamics stratified by initial lesion morphology in an iatrogenic, single-center outbreak of Candida endogenous endophthalmitis (EFE) among immunocompetent patients.

Methods

Of 26 eyes in the original cohort, 18 were classified with chorioretinal involvement and 8 with intraretinal or preretinal involvement.

n = 26 eyes

Results

100.0%

Abnormal new retinal blood vessels developed in all chorioretinal cases, none with intraretinal/preretinal disease.

n = 26 eyes

More results

Although both groups experienced functional improvement after treatment, the chorioretinal group had significantly worse final BCVA at twelve months (median 0.80 versus 0.20 LogMAR; P = 0.005) and a higher overall complication burden (92.3% versus 25.0%; P < 0.001) than the intraretinal or preretinal group.

“

Conclusion · 1 of 3

Initial chorioretinal involvement was associated with poorer visual recovery and a markedly higher incidence of secondary macular neovascularization.

Conclusion · 2 of 3

The early expansion of retinal pigment epithelium lesions alongside visual improvement likely reflects tissue remodeling and may be less suggestive of ongoing infection.

Conclusion · 3 of 3

These findings support routine optical coherence tomography and optical coherence tomography angiography surveillance and timely anti-vascular endothelial growth factor therapy for eyes with chorioretinal involvement.

Post

Twelve-month functional and structural outcomes of Candida endogenous endophthalmitis in immunocompetent patients: a longitudinal cohort study of an outbreak.

Chorioretinal Candida eye infection was linked to abnormal new blood vessel growth in all eyes.

Related papers